Luna County Sheriff's Deputy Trini Garcia said the fire started at before 11 a-m Sunday in a mobile home serving as the business office of Columbus L-P Gas, located at 1550 South Highway 11, north of Columbus.
Emergency dispatchers were notified by witnesses who saw smoke coming from the property.
Garcia said the fire spread to four sheds on the property, and caused a 125-gallon propane tank to explode.
Columbus and Deming fire departments responded to the blaze.
No injuries were reported. The cause of the fire is under investigation.